Pan-Tumor Pathologic Scoring of Response to PD-(L)1 Blockade
نویسندگان
چکیده
منابع مشابه
Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade-mediated tumor regression.
Programmed death-1 receptor (PD-L1, B7-H1) and programmed cell death protein 1 (PD-1) pathway blockade is a promising therapy for treating cancer. However, the mechanistic contribution of host and tumor PD-L1 and PD-1 signaling to the therapeutic efficacy of PD-L1 and PD-1 blockade remains elusive. Here, we evaluated 3 tumor-bearing mouse models that differ in their sensitivity to PD-L1 blockad...
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Chunyan YUE1,2 and Zhiyuan HU1,2,3* 1CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing 100190, P.R. China. 2Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100049, P. R. China 3Yangtze River Delta Academy of Nanotechnology and Industry Devel...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2019
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-19-2379